Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome

Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome

Treatment of Sprague-Dawley rats with AY9944, an inhibitor of 3β-hydroxysterol-Δ7-reductase (Dhcr7), leads to elevated levels of 7-dehydrocholesterol (7-DHC) and reduced levels of cholesterol in all biological tissues, mimicking the key biochemical hallmark of Smith-Lemli-Opitz syndrome (SLOS). Four...

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Bibliographic Details
Main Authors:	Libin Xu, Wei Liu, Lowell G. Sheflin, Steven J. Fliesler, Ned A. Porter
Format:	Article
Language:	English
Published:	Elsevier 2011-10-01
Series:	Journal of Lipid Research
Subjects:	cholesterol cholesterol/biosynthesis lipids/peroxidation 7-dehydrocholesterol
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520408454

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