Clostridium perfringens epsilon toxin targets granule cells in the mouse cerebellum and stimulates glutamate release.

Clostridium perfringens epsilon toxin targets granule cells in the mouse cerebellum and stimulates glutamate release.

Epsilon toxin (ET) produced by C. perfringens types B and D is a highly potent pore-forming toxin. ET-intoxicated animals express severe neurological disorders that are thought to result from the formation of vasogenic brain edemas and indirect neuronal excitotoxicity. The cerebellum is a predilecti...

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Bibliographic Details
Main Authors: Etienne Lonchamp, Jean-Luc Dupont, Laetitia Wioland, Raphaël Courjaret, Corinne Mbebi-Liegeois, Emmanuel Jover, Frédéric Doussau, Michel R Popoff, Jean-Louis Bossu, Jean de Barry, Bernard Poulain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941361/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941361/?tool=EBI

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