Extended-spectrum beta-lactamase-producing community-acquired urinary tract infections in children: Chart review of risk factors

• Main Authors: Sundaram Balasubramanian, Dhanalakshmi Kuppuswamy, Swathi Padmanabhan, Vaishnavi Chandramohan, Sumanth Amperayani
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018-01-01
• Series: Journal of Global Infectious Diseases
• Subjects: Extended-spectrum beta-lactamase; risk factors; urinary tract infections
• Online Access: http://www.jgid.org/article.asp?issn=0974-777X;year=2018;volume=10;issue=4;spage=222;epage=225;aulast=Balasubramanian

Background: Community acquired urinary tract infections (CA-UTI) caused by extended spectrum beta lactamase (ESBL) producing organisms is on the rise throughout the world. There are known risk factors such as age <1 year, children on uroprophylaxis, recurrent UTI, recent antibiotic usage etc which can predict the occurrence of these ESBL producers. Objectives: To correlate known risk factors with occurrence of ESBL UTI and antibiotic susceptibility of uropathogens isolated. Materials and Methods: Clinical and microbiological data were collected from 100 children 1month to 12 years with CA-UTI. The risk factors were compared in the ESBL and non-ESBL group and analysed. Results and Conclusion: The antimicrobial sensitivity pattern in our study showed increased resistance to cephalosporins, cotrimoxazole, fluoroquinolones and amoxicillin-clavulanic acid which are frequently used in the treatment of UTI, with most isolates being sensitive to aminoglycosides, piperacillin-tazobactam and carbapenems. Statistical analysis did not identify any significant risk factor that predisposes to ESBL UTI.