Zebrafish (Danio rerio) as an ecotoxicological model for Nanomaterial induced toxicity profiling

• Main Authors: Suresh K Verma, Aditya Nandi, Adrija Sinha, Paritosh Patel, Ealisha Jha, Swabhiman Mohanty, Pritam Kumar Panda, Rajeev Ahuja, Yogendra Kumar Mishra, Mrutyunjay Suar
• Format: Article
• Language: English
• Published: Andover House Inc. 2021-03-01
• Series: Precision Nanomedicine
• Online Access: https://prnano.scholasticahq.com/article/21978-zebrafish-danio-rerio-as-an-ecotoxicological-model-for-nanomaterial-induced-toxicity-profiling.pdf

With the advancement of technologies, the evolution of nanoscience is occurring at a rapid pace. The demand for nanomaterials in various industries has increased. However, they may pose an increased risk upon exposure to living organisms, demanding toxicological studies. Alt-hough risk assessment of nanomaterials is a challenge due to their varieties in sizes and variabil-ity in properties, different methodologies of toxicity screenings have been used successfully to evaluate the potential risks. Although nanotechnology has contributed to technology develop-ment and well-being, information in these fields is still incomplete. Fortunately, those areas are under continuous research, and there are increasing experimental efforts in determining the envi-ronmental effects on humans exposed to nanoparticles. Since the field of nanotechnology is continuously expanding, we need medium- to high throughput nanotoxicity screenings to deter-mine any potential risks caused by nanomaterials. Zebrafish, a well-established model for mammalian research, have advantages when used in these toxicity screenings. This review de-scribes various kinds of toxicities induced in zebrafish embryos by different kinds of nanopar-ticles. A significant number of experimental data from toxicological studies are also presented that determine nanomaterials' effects, which can be modulated or further mitigated to create a positive impact on living organisms.