Chromosomal aberrations induced by ionizing radiation at different doses

• Main Authors: Anisoara Nevoie, Mihaela Pascariu, Ivanov Iuliu, Daniela Jitaru, Lucian Negura, Eugen Carasevici
• Format: Article
• Language: English
• Published: "Alexandru Ioan Cuza" University of Iași 2010-06-01
• Series: Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara
• Online Access: http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/765

The present study was designed to evaluate the in vitro effect of ionizing radiation in human peripheral blood mononuclear cell cultures. We studied the chromosomal aberration induced by X ray in normal human peripheral blood mononuclear cell cultures. Different doses (0.8 Gy, 2 Gy and 5 Gy) for irradiation of human cell cultures were used for this study. Chromosome aberration analysis was carried out at 48 and 72 hours from irradiation. Radiation- induced chromosomal modifications were detected by karyotyping. The obtained results strongly suggest that normal cells can repair at low doses.