IL-10 Combined with NGAL Has Diagnostic Value for AECOPD Combined with AKI

• Main Authors: Wei B, Tian T, Liu YG
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-03-01
• Series: International Journal of COPD
• Subjects: chronic obstructive pulmonary disease; acute exacerbation; acute kidney injury; inflammatory factors; diagnosis
• Online Access: https://www.dovepress.com/il-10-combined-with-ngal-has-diagnostic-value-for-aecopd-combined-with-peer-reviewed-article-COPD

Bing Wei, Tian Tian, Yu-Geng Liu Department of Emergency Medicine, Beijing Chaoyang Hospital Jingxi Branch, Capital Medical University, Beijing 100043, People’s Republic of ChinaCorrespondence: Yu-Geng LiuDepartment of Emergency Medicine, Beijing Chaoyang Hospital Jingxi Branch, Capital Medical University, No. 5 Jingyuan Road, Shijingshan District, Beijing 100043, People’s Republic of ChinaTel [phone]Email [e-mail]: In patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated by acute kidney injury (AKI) has an acute onset and seriously affects the prognosis of patients. The inflammatory factors are still in doubt in the diagnosis of AECOPD with AKI.Material and Methods: This study is a retrospective study. By collecting the plasma concentrations of inflammatory factors IFN-γ, IL-2, IL-4, IL-10, IL-17, and NGAL in patients with AECOPD group, AECOPD plus AKI group, and control group. The expression level of each factor among the three different groups was analyzed, and the correlation of each factor was analyzed. The diagnostic value of each factor in patients with AECOPD combined with AKI was tested.Results: A total of 245 cases of AECOPD, 69 cases of AECOPD with AKI, and 50 healthy control group were included in this study. IFN-γ and IL-4 were differentially expressed among the three groups (P < 0.001). However, there was no difference between the AECOPD group and the AECOPD + AKI group (P = 0.153, and 0.070, respectively). The expression of IL-2, IL-10, IL-17, and NGAL in the three groups were different, and there are statistical differences in pairwise comparisons. (all P values are < 0.001). The univariate analysis showed that NGAL and IL-10 with the best correlation (r = 0.696). The ROC curve shows that IL-10 and NGAL have better diagnostic value for AECOPD with AKI.Conclusion: The inflammatory factor IL-10 combined with NGAL has a better diagnostic value for AECOPD with AKI.Keywords: chronic obstructive pulmonary disease, acute exacerbation, acute kidney injury, inflammatory factors, diagnosis