Healing of Ocular Herpetic Disease Following Treatment With an Engineered FGF-1 Is Associated With Increased Corneal Anti-Inflammatory M2 Macrophages

Healing of Ocular Herpetic Disease Following Treatment With an Engineered FGF-1 Is Associated With Increased Corneal Anti-Inflammatory M2 Macrophages

Herpes simplex virus 1 (HSV-1) infects the cornea and caused blinding ocular disease. In the present study, we evaluated whether and how a novel engineered version of fibroblast growth factor-1 (FGF-1), designated as TTHX1114, would reduce the severity of HSV-1-induced and recurrent ocular herpes in...

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Bibliographic Details
Main Authors: Nisha R. Dhanushkodi, Ruchi Srivastava, Pierre-Gregoire A. Coulon, Swayam Prakash, Soumyabrata Roy, Didier Bagnol, Eveleth D. David, Lbachir BenMohamed
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
FGF-1
inflammatory macrophage
HSV-1
infection
eye
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.673763/full

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