Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca2+-Independent Mechanism

Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca2+-Independent Mechanism

Exposure of U937 cells to peroxynitrite promotes mitochondrial superoxide formation via a mechanism dependent on both inhibition of complex III and increased mitochondrial Ca2+ accumulation. Otherwise inactive concentrations of the oxidant produced the same maximal effects in the presence of either...

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Bibliographic Details
Main Authors: Andrea Guidarelli, Liana Cerioni, Mara Fiorani, Orazio Cantoni
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:International Journal of Molecular Sciences
Subjects:
peroxynitrite
ascorbic acid
mitochondrial superoxide
DNA damage
mitochondrial dysfunction
complex III
Online Access:https://www.mdpi.com/1422-0067/18/8/1686

Internet

https://www.mdpi.com/1422-0067/18/8/1686

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