Cellular Uptake and Photo-Cytotoxicity of a Gadolinium(III)-DOTA-Naphthalimide Complex “Clicked” to a Lipidated Tat Peptide

Cellular Uptake and Photo-Cytotoxicity of a Gadolinium(III)-DOTA-Naphthalimide Complex “Clicked” to a Lipidated Tat Peptide

A new bifunctional macrocyclic chelator featuring a conjugatable alkynyl-naphthalimide fluorophore pendant group has been prepared and its Gd(III) complex coupled to a cell-penetrating lipidated azido-Tat peptide derivative using Cu(I)-catalysed “click” chemistry. The resulting fluorescent conjugate...

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Bibliographic Details
Main Authors: William I. O’Malley, Riccardo Rubbiani, Margaret L. Aulsebrook, Michael R. Grace, Leone Spiccia, Kellie L. Tuck, Gilles Gasser, Bim Graham
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:Molecules
Subjects:
cell-penetrating peptide
fluorescence
gadolinium complex
photo-cytotoxicity
theranostic
Online Access:http://www.mdpi.com/1420-3049/21/2/194

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