Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids

Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids

A selection of potential bioactive molecules including alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids using virtual screening has been carried out and their biological activity was determined. The studied substances proved to be low-toxic, biologically active compounds. It was establishe...

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Main Authors: O. О. Brazhko, M. P. Zavgorodny, O. S. Kruglyak, L. O. Omeljanchik, G. A. Shapoval
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2015-04-01
Series:Ukrainian Biochemical Journal
Subjects:
4-thioquinolines
antiradical and antioxidant activity
mercaptocarboxylic acids
PASS-prognosis
toxicity
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2015/05/Brazhko_2_15.pdf
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spelling doaj-d84fa9f3b53c4ec2ae70abddb7bf234a2020-11-24T23:04:53ZengNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.Ukrainian Biochemical Journal2409-49432413-50032015-04-018729510210.15407/ubj87.02.095Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acidsO. О. Brazhko0M. P. Zavgorodny1O. S. Kruglyak2L. O. Omeljanchik3G. A. Shapoval4Zaporizhzhya National University, UkraineZaporizhzhya National University, UkraineInstitute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, KyivZaporizhzhya National University, UkraineInstitute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, KyivA selection of potential bioactive molecules including alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids using virtual screening has been carried out and their biological activity was determined. The studied substances proved to be low-toxic, biologically active compounds. It was established that 4-thio derivatives of quinoline exhibit pronounced antiradical, antioxidant effects and can act as preventive antioxidants, radio and cytoprotectors.http://ukrbiochemjournal.org/wp-content/uploads/2015/05/Brazhko_2_15.pdf4-thioquinolinesantiradical and antioxidant activitymercaptocarboxylic acidsPASS-prognosistoxicity
collection DOAJ
language English
format Article
sources DOAJ
author O. О. Brazhko
M. P. Zavgorodny
O. S. Kruglyak
L. O. Omeljanchik
G. A. Shapoval
spellingShingle O. О. Brazhko
M. P. Zavgorodny
O. S. Kruglyak
L. O. Omeljanchik
G. A. Shapoval
Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids
Ukrainian Biochemical Journal
4-thioquinolines
antiradical and antioxidant activity
mercaptocarboxylic acids
PASS-prognosis
toxicity
author_facet O. О. Brazhko
M. P. Zavgorodny
O. S. Kruglyak
L. O. Omeljanchik
G. A. Shapoval
author_sort O. О. Brazhko
title Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids
title_short Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids
title_full Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids
title_fullStr Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids
title_full_unstemmed Antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids
title_sort antioxidant activity of alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids
publisher National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
series Ukrainian Biochemical Journal
issn 2409-4943
2413-5003
publishDate 2015-04-01
description A selection of potential bioactive molecules including alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids using virtual screening has been carried out and their biological activity was determined. The studied substances proved to be low-toxic, biologically active compounds. It was established that 4-thio derivatives of quinoline exhibit pronounced antiradical, antioxidant effects and can act as preventive antioxidants, radio and cytoprotectors.
topic 4-thioquinolines
antiradical and antioxidant activity
mercaptocarboxylic acids
PASS-prognosis
toxicity
url http://ukrbiochemjournal.org/wp-content/uploads/2015/05/Brazhko_2_15.pdf
work_keys_str_mv AT oobrazhko antioxidantactivityofalkoxyderivativesofquinoline4ylthiocarboxylicacids
AT mpzavgorodny antioxidantactivityofalkoxyderivativesofquinoline4ylthiocarboxylicacids
AT oskruglyak antioxidantactivityofalkoxyderivativesofquinoline4ylthiocarboxylicacids
AT loomeljanchik antioxidantactivityofalkoxyderivativesofquinoline4ylthiocarboxylicacids
AT gashapoval antioxidantactivityofalkoxyderivativesofquinoline4ylthiocarboxylicacids
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