Association of GST gene polymorphism and noise-induced hearing loss<br /> <em>Running title: GST gene polymorphism and NIHL</em>

• Main Authors: Ziba Loukzadeh, Hadi Eshaghi Sani, Mohammad Hasan Sheikhha, Farzaneh Morteza Ratki
• Format: Article
• Language: English
• Published: AIMS Press 2019-12-01
• Series: AIMS Public Health
• Subjects: noise; noise induced hearing loss; polymorphism; gstt1; gstm1
• Online Access: https://www.aimspress.com/article/10.3934/publichealth.2019.4.546/fulltext.html

<em>Background:</em> It has been proposed that Noise-induced hearing loss is a complex disease that is combination of environmental and genetic factors. There are inconsistent results concerning the association between variation in glutathione S-transferase (<em>GST</em>) genetic polymorphisms (<em>GSTT1</em> rs1049055 and <em>GSTM1</em> rs10712361) and susceptibility to Noise-induced hearing loss. <em>Objective:</em> This study was designed to assess the association between GST gene polymorphism and Noise-induced hearing loss among noise-exposed workers. <em>Methods:</em> In a case-control study, male workers from tile and ceramic factories were selected randomly. Subjects were classified into two groups according to the result of audiometry: 73 subjects showed Noise-induced hearing loss which was considered in the case group and 87 subjects without hearing loss was enrolled in the control group. The <em>GSTT1</em> and <em>GSTM1</em> polymorphism of both groups were assessed by multiplex polymerase chain reaction. Results: Null <em>GSTT1</em> and <em>GSTM1</em> genotypes were more frequent in case group but no significant statistical difference was seen in case and control groups. No significant link between <em>GSTT1</em> and <em>GSTM1</em> genotypes was found. <em>Conclusion:</em> This study suggests that the genetic variability of <em>GSTT1</em> and <em>GSTM1</em> has no effect on susceptibility to noise induced hearing loss.