Canagliflozin, an SGLT-2 inhibitor, ameliorates acetic acid-induced colitis in rats through targeting glucose metabolism and inhibiting NOX2

Canagliflozin, an SGLT-2 inhibitor, ameliorates acetic acid-induced colitis in rats through targeting glucose metabolism and inhibiting NOX2

Background: Inflammatory bowel disease is defined as chronic noninfectious inflammation of the gastrointestinal tract, including ulcerative colitis and Crohn’s disease. Its incidence and predominance have increased globally, with no effective agents for preventing its recurrence or treatment until n...

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Bibliographic Details
Main Authors: Mohamed A. Morsy, Hanaa M. Khalaf, Rehab A. Rifaai, Asmaa M.A. Bayoumi, Esraa M.M.A. Khalifa, Yasmine F. Ibrahim
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Acetic acid-induced colitis
Canagliflozin
SGLT-2
Inflammatory response
NOX2
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221006843

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http://www.sciencedirect.com/science/article/pii/S0753332221006843

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