Gastrointestinal Stromal Tumors of the Small Intestine: Progress in Diagnosis and Treatment Research

• Main Authors: Peng F, Liu Y
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-05-01
• Series: Cancer Management and Research
• Subjects: gastrointestinal stromal tumors (gists); small intestine; novel treatment; preoperative tumor staging; karyokinesis exponent; exosomes.
• Online Access: https://www.dovepress.com/gastrointestinal-stromal-tumors-of-the-small-intestine-progress-in-dia-peer-reviewed-article-CMAR

Fangxing Peng,1,2 Yao Liu1,2 1Gastrointestinal Surgery, No. 2 Affiliated Hospital of North Sichuan Medical College, Mianyang, Sichuan Province 621000, People’s Republic of China; 2Gastrointestinal Surgery, Sichuan Mianyang 404 Hospital, Mianyang, Sichuan Province 621000, People’s Republic of ChinaCorrespondence: Fangxing Peng Tel [phone]Email [e-mail]: In recent years, the diagnosis and treatment of gastrointestinal stromal tumors (GISTs) of the small intestine have been a hot topic due to their rarity and non-specific clinical manifestations. With the development of gene and imaging technology, surgery, and molecular targeted drugs, the diagnosis and treatment of GISTs have achieved great success. For a long time, radical resection was prioritized to treat GISTs of the small intestine. At present, preoperative tumor staging is a novel treatment for unresectable malignant tumors. In addition, karyokinesis exponent is the sole independent predictor of progression-free survival of GISTs. The DNA, miRNA, and protein of exosomes have also been found to be biomarkers with prognostic implications. The research on the treatment of GISTs has become a focus in the era of precision medicine, ushering in the use of standardized, normalized, and individualized treatment.Keywords: gastrointestinal stromal tumors, GISTs, small intestine, novel treatment, preoperative tumor staging, karyokinesis exponent, exosomes