Salviva®: Step forward in human saliva substitution

• Main Authors: Marković Srđan Z., Serafimovka Adrijana Z., Kostić Ivana T., Jovović Marija Đ., Ribar Maja M., Bugarski Branko M., Kastratović Dragana A.
• Format: Article
• Language: English
• Published: Srpsko lekarsko drustvo 2020-01-01
• Series: Hospital Pharmacology
• Subjects: saliva; xerostomia; dry mouth; medical device
• Online Access: https://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2020/2334-94922003976M.pdf

Introduction: Saliva is a product of salivary glands secretion that constantly soaks-moisturizes the teeth and mucous membranes of the oral cavity. Physiological roles of saliva are: maintaining humidity, lubrication and physiological cleaning of the oral cavity, enzymatic activity (beginning of digestion), bacteriostatic and bactericidal action, prevention of dental caries. Topic: The most serious health problem is the complete, permanent absence of saliva secretion , which is an absolute indication for daily use of an adequate preparation for moistening the oral cavity or saliva substitution. Salviva ® is sufficiently viscous and the content that can serve as natural saliva for 4 hours. 200 ml bottle is sufficient for daily patient needs and the production costs are low (0.25 EUR per unit for laboratory level volumes, excluding primary packaging costs). Conclusions: With the further innovative development of Salviva ® , it is possible to apply drugs with local and systemic effects, and thus treat the patient, which opens a completely new field of application of some drugs and reduces their side effects and unpleasant effects. The quality of life of patients as well as social functionality will be significantly improved, which is very important for the working population.