QSAR Study of p56lck Protein Tyrosine Kinase Inhibitory Activity of Flavonoid Derivatives Using MLR and GA-PLS

QSAR Study of p56lck Protein Tyrosine Kinase Inhibitory Activity of Flavonoid Derivatives Using MLR and GA-PLS

Quantitative relationships between molecular structure and p56lck protein tyrosine kinase inhibitory activity of 50 flavonoid derivatives are discovered by MLR and GA-PLS methods. Different QSAR models revealed that substituent electronic descriptors (SED) parameters have significant impact on prote...

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Bibliographic Details
Main Authors: Razieh Sabet, Afshin Fassihi
Format: Article
Language:English
Published: MDPI AG 2008-09-01
Series:International Journal of Molecular Sciences
Subjects:
Protein tyrosine kinase
Flavonoid
QSAR
Chemometrics
SED analysis
Online Access:http://www.mdpi.com/1422-0067/9/9/1876/

Internet

http://www.mdpi.com/1422-0067/9/9/1876/

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