Detection of anticancer drug by electrochemical sensors at Modified Electrode (MWCNT/polyEosin-Y)

• Main Authors: Eman A. M. Al-Jawadi, Mohammed I. Majeed
• Format: Article
• Language: English
• Published: Iranian Society of Nanomedicine 2021-01-01
• Series: Nanomedicine Research Journal
• Subjects: vp-16; anticancer drug; poly eosin-y; cyclic voltammetry; mwcnt
• Online Access: http://www.nanomedicine-rj.com/article_241825_cb250f530b63ae0e57361379ce4274ab.pdf
• ISSN: 2476-3489; 2476-7123

In this research, a biosensor was developed to evaluate VP-16 Which is used in the treatment of several tumors, including small lung cancers, testicular cancer, The sensor is generated by modifying bare GCE with Eosin-Y(yellowish)(EOY) using MWCNT electropolymerization (PEOY-MWCNT / GCE) at pH 6.0 by using cyclic voltammetry technique with a scanning rate of 50 mV.s−1 with 14 cycles for the optimum number of cycles . A number of variables were analyzed, which in turn controlled the sensor 's efficiency and functioning and were mounted for use in experiments while developing the sensor, One of these variables is to choose the best pH at which the material on the surface of the GCE electrode can be calculated to choose the best pH 7 as the best measuring variable . To ensure completion of electrochemical polymerization on the electrode surface by visualizing the electrode surface properties by scanning an electron microscope (SEM), which describes PEOY/GCE and MWCNTs/PEOY/GCE morphology, The variables related to the EOY polymerization process were tested for more accuracy in the analysis, and the best values were selected to produce the best result. The electrodes used for the analysis were then tested separately by analyzing the findings and it was noticed that the PEOY / VP-16 / GCE electrode provides a better measurement of the bare electrode and in effect the presence of multi-walled carbon nanotubes gives a higher measurement of all the electrodes.