STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow ion passage through the pore.

Bibliographic Details
Main Authors: Megumi Yamashita, Priscilla S.-W. Yeung, Christopher E. Ing, Beth A. McNally, Régis Pomès, Murali Prakriya
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14512
id doaj-d822026f02ee422589e1d171ef62a857
record_format Article
spelling doaj-d822026f02ee422589e1d171ef62a8572021-05-11T07:44:11ZengNature Publishing GroupNature Communications2041-17232017-02-018111310.1038/ncomms14512STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gateMegumi Yamashita0Priscilla S.-W. Yeung1Christopher E. Ing2Beth A. McNally3Régis Pomès4Murali Prakriya5Department of Pharmacology, Feinberg School of Medicine, Northwestern UniversityDepartment of Pharmacology, Feinberg School of Medicine, Northwestern UniversityMolecular Structure and Function, Hospital for Sick Children, University of TorontoDepartment of Pharmacology, Feinberg School of Medicine, Northwestern UniversityMolecular Structure and Function, Hospital for Sick Children, University of TorontoDepartment of Pharmacology, Feinberg School of Medicine, Northwestern UniversityStore-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow ion passage through the pore.https://doi.org/10.1038/ncomms14512
collection DOAJ
language English
format Article
sources DOAJ
author Megumi Yamashita
Priscilla S.-W. Yeung
Christopher E. Ing
Beth A. McNally
Régis Pomès
Murali Prakriya
spellingShingle Megumi Yamashita
Priscilla S.-W. Yeung
Christopher E. Ing
Beth A. McNally
Régis Pomès
Murali Prakriya
STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
Nature Communications
author_facet Megumi Yamashita
Priscilla S.-W. Yeung
Christopher E. Ing
Beth A. McNally
Régis Pomès
Murali Prakriya
author_sort Megumi Yamashita
title STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_short STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_full STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_fullStr STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_full_unstemmed STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_sort stim1 activates crac channels through rotation of the pore helix to open a hydrophobic gate
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-02-01
description Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow ion passage through the pore.
url https://doi.org/10.1038/ncomms14512
work_keys_str_mv AT megumiyamashita stim1activatescracchannelsthroughrotationoftheporehelixtoopenahydrophobicgate
AT priscillaswyeung stim1activatescracchannelsthroughrotationoftheporehelixtoopenahydrophobicgate
AT christophereing stim1activatescracchannelsthroughrotationoftheporehelixtoopenahydrophobicgate
AT bethamcnally stim1activatescracchannelsthroughrotationoftheporehelixtoopenahydrophobicgate
AT regispomes stim1activatescracchannelsthroughrotationoftheporehelixtoopenahydrophobicgate
AT muraliprakriya stim1activatescracchannelsthroughrotationoftheporehelixtoopenahydrophobicgate
_version_ 1721451812302618624

Similar Items