Transplantation in the nonhuman primate MPTP model of Parkinson's disease: update and perspectives
In order to calibrate stem cell exploitation for cellular therapy in neurodegenerative diseases, fundamental and preclinical research in NHP (nonhuman primate) models is crucial. Indeed, it is consensually recognized that it is not possible to directly extrapolate results obtained in rodent models...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Copernicus Publications
2017-10-01
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| Series: | Primate Biology |
| Online Access: | https://www.primate-biol.net/4/185/2017/pb-4-185-2017.pdf |
| Summary: | In order to calibrate stem cell exploitation for cellular therapy in
neurodegenerative diseases, fundamental and preclinical research in NHP
(nonhuman primate) models is crucial. Indeed, it is consensually recognized that it is not possible to directly extrapolate results obtained in rodent models to human
patients. A large diversity of neurological pathologies should benefit from
cellular therapy based on neural differentiation of stem cells. In the
context of this special issue of Primate Biology on NHP stem cells, we
describe past and recent advances on cell replacement in the NHP model of
Parkinson's disease (PD). From the different grafting procedures to the various
cell types transplanted, we review here diverse approaches for
cell-replacement therapy and their related therapeutic potential on behavior
and function in the NHP model of PD. |
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| ISSN: | 2363-4707 2363-4715 |