On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models

On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models

The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrat...

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Bibliographic Details
Main Author: Mihai V. Putz
Format: Article
Language:English
Published: MDPI AG 2011-04-01
Series:Molecules
Subjects:
W-Lambert equation
logistic transformation
cholinesterases
fitting curves
kinetic parameters
Online Access:http://www.mdpi.com/1420-3049/16/4/3128/
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spelling doaj-d8154ee7c2814dae825ecdb8a8d1b7f82020-11-24T23:12:49ZengMDPI AGMolecules1420-30492011-04-011643128314510.3390/molecules16043128On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten ModelsMihai V. PutzThe conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrate concentration, through detailed initial rate and progress curve analysis, even when other classical conditions for such equivalence are not entirely fulfilled. http://www.mdpi.com/1420-3049/16/4/3128/W-Lambert equationlogistic transformationcholinesterasesfitting curveskinetic parameters
collection DOAJ
language English
format Article
sources DOAJ
author Mihai V. Putz
spellingShingle Mihai V. Putz
On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
Molecules
W-Lambert equation
logistic transformation
cholinesterases
fitting curves
kinetic parameters
author_facet Mihai V. Putz
author_sort Mihai V. Putz
title On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_short On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_full On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_fullStr On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_full_unstemmed On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_sort on the reducible character of haldane-radić enzyme kinetics to conventional and logistic michaelis-menten models
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2011-04-01
description The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrate concentration, through detailed initial rate and progress curve analysis, even when other classical conditions for such equivalence are not entirely fulfilled.
topic W-Lambert equation
logistic transformation
cholinesterases
fitting curves
kinetic parameters
url http://www.mdpi.com/1420-3049/16/4/3128/
work_keys_str_mv AT mihaivputz onthereduciblecharacterofhaldaneradicenzymekineticstoconventionalandlogisticmichaelismentenmodels
_version_ 1725600632163794944

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