Piperlongumine Attenuates High Calcium/Phosphate-Induced Arterial Calcification by Preserving P53/PTEN Signaling

Piperlongumine Attenuates High Calcium/Phosphate-Induced Arterial Calcification by Preserving P53/PTEN Signaling

Vascular calcification frequently occurs in the process of chronic kidney disease, atherosclerosis and aging, resulting in an increased prevalence of cardiovascular events. Piperlongumine (PLG) is a natural product isolated from Piper longum L. Here, we aimed to explore the effect of PLG in high cal...

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Bibliographic Details
Main Authors: Wenxiang Shi, Jieyu Lu, Junhan Li, Ming Qiu, Yan Lu, Jia Gu, Xiangqing Kong, Wei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
piperlongumine
P53
PTEN
vascular calcification
VSMCs
STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.625215/full

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