Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape

Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape

The COPII coat assembles in two concentric layers and mediates protein export from the endoplasmic reticulum. Here the authors present the 4.9 Å resolution cryo-tomography and subtomogram averaging structure of the membrane bound COPII inner coat that was obtained by in vitro reconstitution and disc...

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Main Authors: Joshua Hutchings, Viktoriya Stancheva, Elizabeth A. Miller, Giulia Zanetti
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06577-4
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spelling doaj-d805b15fd8a0450ebdba300c73ed83112021-05-11T09:51:44ZengNature Publishing GroupNature Communications2041-17232018-10-01911810.1038/s41467-018-06577-4Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shapeJoshua Hutchings0Viktoriya Stancheva1Elizabeth A. Miller2Giulia Zanetti3Institute of Structural and Molecular Biology, Birkbeck CollegeMRC Laboratory of Molecular BiologyMRC Laboratory of Molecular BiologyInstitute of Structural and Molecular Biology, Birkbeck CollegeThe COPII coat assembles in two concentric layers and mediates protein export from the endoplasmic reticulum. Here the authors present the 4.9 Å resolution cryo-tomography and subtomogram averaging structure of the membrane bound COPII inner coat that was obtained by in vitro reconstitution and discuss mechanistic implications.https://doi.org/10.1038/s41467-018-06577-4
collection DOAJ
language English
format Article
sources DOAJ
author Joshua Hutchings
Viktoriya Stancheva
Elizabeth A. Miller
Giulia Zanetti
spellingShingle Joshua Hutchings
Viktoriya Stancheva
Elizabeth A. Miller
Giulia Zanetti
Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape
Nature Communications
author_facet Joshua Hutchings
Viktoriya Stancheva
Elizabeth A. Miller
Giulia Zanetti
author_sort Joshua Hutchings
title Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape
title_short Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape
title_full Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape
title_fullStr Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape
title_full_unstemmed Subtomogram averaging of COPII assemblies reveals how coat organization dictates membrane shape
title_sort subtomogram averaging of copii assemblies reveals how coat organization dictates membrane shape
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description The COPII coat assembles in two concentric layers and mediates protein export from the endoplasmic reticulum. Here the authors present the 4.9 Å resolution cryo-tomography and subtomogram averaging structure of the membrane bound COPII inner coat that was obtained by in vitro reconstitution and discuss mechanistic implications.
url https://doi.org/10.1038/s41467-018-06577-4
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AT elizabethamiller subtomogramaveragingofcopiiassembliesrevealshowcoatorganizationdictatesmembraneshape
AT giuliazanetti subtomogramaveragingofcopiiassembliesrevealshowcoatorganizationdictatesmembraneshape
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