Polyalkoxy Nitrones as Chiral Building Blocks in Asymmetric Synthesis

Polyalkoxy Nitrones as Chiral Building Blocks in Asymmetric Synthesis

Optically active nitrones derived from both aldoses and dialdoses add metallated heterocycles in a stereocontrolled way depending on the nature of the Lewis acid used as a precomplexing agent of the nitrone. Further elaborations of the resulting hydroxylamines lead to the development of new syntheti...

Full description

Bibliographic Details
Main Authors: Tomás Tejero, Pedro Merino
Format: Article
Language:English
Published: MDPI AG 1999-06-01
Series:Molecules
Subjects:
Nitrones
hydroxylamines
carbohydrates
aminoacids
aminoaldehydes
Online Access:http://www.mdpi.com/1420-3049/4/7/169/
Description
Summary:Optically active nitrones derived from both aldoses and dialdoses add metallated heterocycles in a stereocontrolled way depending on the nature of the Lewis acid used as a precomplexing agent of the nitrone. Further elaborations of the resulting hydroxylamines lead to the development of new synthetic methodologies for the preparation of polyalkoxy α-amino aldehydes and α-amino acids. These compounds can be used as key advanced intermediates in the synthesis of a wide range of natural products and derivatives including amino sugars, aza sugars, and complex nucleosides.
ISSN:1420-3049

Similar Items