Synthesis and Biological Evaluation of Benzodioxole Derivatives as Potential Anticancer and Antioxidant agents

Synthesis and Biological Evaluation of Benzodioxole Derivatives as Potential Anticancer and Antioxidant agents

a series of benzodioxole compounds were synthesized and evaluated for their cytotoxic activity against cervical (Hela), colorectal (Caco-2), and liver (Hep3B) cancer cell lines. Compounds 5a, 5b, 6a, 6b, 7a and 7b showed very weak or negligible anticancer activity with IC50 3.94-9.12 mM. On the cont...

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Bibliographic Details
Main Authors: Hawash Mohammed, Eid Ahmad M, Jaradat Nidal, Abualhasan Murad, Amer Johnny, Naser Zaid Abdel, Draghmeh Saja, Daraghmeh Donia, Daraghmeh Haifa, Shtayeh Tahrir, Sawaftah Hadeel, Mousa Ahmed
Format: Article
Language:English
Published: De Gruyter 2020-11-01
Series:Heterocyclic Communications
Subjects:
benzodioxole
anticancer
antioxidant
doxorubicin
trolox
Online Access:http://www.degruyter.com/view/j/hc.2020.26.issue-1/hc-2020-0105/hc-2020-0105.xml?format=INT

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http://www.degruyter.com/view/j/hc.2020.26.issue-1/hc-2020-0105/hc-2020-0105.xml?format=INT

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