Sequence Read Depth Analysis of a Monophyletic Cluster of Y Chromosomes Characterized by Structural Rearrangements in the AZFc Region Resulting in DYS448 Deletion and DYF387S1 Duplication

Sequence Read Depth Analysis of a Monophyletic Cluster of Y Chromosomes Characterized by Structural Rearrangements in the AZFc Region Resulting in DYS448 Deletion and DYF387S1 Duplication

The azoospermia factor c region (AZFc), located in the long arm of the human Y chromosome, is frequently involved in chromosome rearrangements, mainly due to non-allelic homologous recombination events that occur between the nearly identical sequences (amplicon) that comprises it. These rearrangemen...

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Bibliographic Details
Main Authors: Francesco Ravasini, Eugenia D’Atanasio, Maria Bonito, Biancamaria Bonucci, Chiara Della Rocca, Andrea Berti, Beniamino Trombetta, Fulvio Cruciani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Genetics
Subjects:
Y chromosome
Y-STR
AZFc
genomic rearrangement
infertility
forensic genetics
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.669405/full

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