The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs

Aim. Determine the activity of apoptosis processes in young children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs. Material and methods. The content of caspase-7 and caspase-9 was identified in blood serum of 87 kids by the method of imm...

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Main Authors: H. O. Lezhenko, A. V. Abramov, A. O. Pohribna
Format: Article
Language:English
Published: Zaporozhye State Medical University 2019-09-01
Series:Patologìâ
Subjects:
Online Access:http://pat.zsmu.edu.ua/article/view/177112/178406
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spelling doaj-d7f38605265b43e3adbcd346a6696b522020-11-25T00:44:06ZengZaporozhye State Medical UniversityPatologìâ2306-80272310-12372019-09-0116217718110.14739/2310-1237.2019.2.177112The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organsH. O. LezhenkoA. V. AbramovA. O. PohribnaAim. Determine the activity of apoptosis processes in young children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs. Material and methods. The content of caspase-7 and caspase-9 was identified in blood serum of 87 kids by the method of immunoenzyme assay. Main group included 57 kids with acute bacterial diseases of the respiratory tract (38 patients had acute bacterial bronchitis, 19 - pneumonia). The main group was divided into two subgroups. The first subgroup included 27 children with developed anemia of inflammation acquired on the background of acute bacterial disease of the respiratory tract. Second subgroup - 30 children with acute bacterial diseases of the respiratory tract without anemia. Experimental group - 10 children with iron deficiency anemia without symptoms of inflammatory diseases of the respiratory system. The control group was represented by 20 conditionally healthy children. Results. The presence of pneumonia in children was accompanied by the highest numbers of caspase-9 (14.8 ± 1.8 ng/ml), which was almost 3 times higher than the control group (5.82 ± 0.58 ng/ml). The levels of the studied enzyme were 1.6 times lower in patients with bacterial bronchitis (8.34 ± 0.90 ng/ml), which was significantly higher (P < 0.05) than in the control group. The content of caspase-7 in the experimental group and the 2nd subgroup of the main group did not differ from the control group (P > 0.05) (0.38 ± 0.03 ng/ml and 0.32 ± 0.02 ng/ml), and children of the 1st subgroup (0.27 ± 0.02 ng/ml) showed its significant decrease. Conclusions. Anemia of inflammation in children with acute bacterial diseases of respiratory organs is accompanied by the activation of apoptosis, which, obviously, is inefficient due to the nature of the active necrotic processes acquired on the background of acute inflammation. http://pat.zsmu.edu.ua/article/view/177112/178406infantsrespiratory tract diseasescaspase-7caspase-9anemia of inflammation
collection DOAJ
language English
format Article
sources DOAJ
author H. O. Lezhenko
A. V. Abramov
A. O. Pohribna
spellingShingle H. O. Lezhenko
A. V. Abramov
A. O. Pohribna
The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs
Patologìâ
infants
respiratory tract diseases
caspase-7
caspase-9
anemia of inflammation
author_facet H. O. Lezhenko
A. V. Abramov
A. O. Pohribna
author_sort H. O. Lezhenko
title The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs
title_short The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs
title_full The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs
title_fullStr The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs
title_full_unstemmed The content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs
title_sort content of apoptosis mediators in children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs
publisher Zaporozhye State Medical University
series Patologìâ
issn 2306-8027
2310-1237
publishDate 2019-09-01
description Aim. Determine the activity of apoptosis processes in young children with anemia of inflammation acquired on the background of acute bacterial diseases of respiratory organs. Material and methods. The content of caspase-7 and caspase-9 was identified in blood serum of 87 kids by the method of immunoenzyme assay. Main group included 57 kids with acute bacterial diseases of the respiratory tract (38 patients had acute bacterial bronchitis, 19 - pneumonia). The main group was divided into two subgroups. The first subgroup included 27 children with developed anemia of inflammation acquired on the background of acute bacterial disease of the respiratory tract. Second subgroup - 30 children with acute bacterial diseases of the respiratory tract without anemia. Experimental group - 10 children with iron deficiency anemia without symptoms of inflammatory diseases of the respiratory system. The control group was represented by 20 conditionally healthy children. Results. The presence of pneumonia in children was accompanied by the highest numbers of caspase-9 (14.8 ± 1.8 ng/ml), which was almost 3 times higher than the control group (5.82 ± 0.58 ng/ml). The levels of the studied enzyme were 1.6 times lower in patients with bacterial bronchitis (8.34 ± 0.90 ng/ml), which was significantly higher (P < 0.05) than in the control group. The content of caspase-7 in the experimental group and the 2nd subgroup of the main group did not differ from the control group (P > 0.05) (0.38 ± 0.03 ng/ml and 0.32 ± 0.02 ng/ml), and children of the 1st subgroup (0.27 ± 0.02 ng/ml) showed its significant decrease. Conclusions. Anemia of inflammation in children with acute bacterial diseases of respiratory organs is accompanied by the activation of apoptosis, which, obviously, is inefficient due to the nature of the active necrotic processes acquired on the background of acute inflammation.
topic infants
respiratory tract diseases
caspase-7
caspase-9
anemia of inflammation
url http://pat.zsmu.edu.ua/article/view/177112/178406
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