Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function.

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function.

Activation of the nuclear hormone receptor, PPARγ, with pharmacological agonists promotes a contractile vascular smooth muscle cell phenotype and reduces oxidative stress and cell proliferation, particularly under pathological conditions including vascular injury, restenosis, and atherosclerosis. Ho...

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Bibliographic Details
Main Authors: Jennifer M Kleinhenz, Tamara C Murphy, Anastassia P Pokutta-Paskaleva, Rudolph L Gleason, Alicia N Lyle, W Robert Taylor, Mitsi A Blount, Juan Cheng, Qinglin Yang, Roy L Sutliff, C Michael Hart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4599849?pdf=render

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