EFFICACY AND SAFETY OF TOPICAL CHOLECALCIFEROL, CALCITRIOL, AND CALCIPOTRIOL IN THE TREATMENT OF PLAQUE PSORIASIS: A COMPARATIVE STUDY

• Main Authors: M. Samini, H. Seirafi H. R. Efitekhari
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 1998-07-01
• Series: Acta Medica Iranica
• Subjects: Cholecalciferol; calcitriol; calcipotrioi
• Online Access: http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/4896.pdf&manuscript_id=4896

The present work compared the clinical efficacy of ropically applied vitamin D3 (Cholecalciferol), I a, 25 dihydroxy vitamin D3 (cakitriol) with calcipotriol (Dovonex} in the treatment of plaque psoriasis. A randomized, double - blind, left - right, vehicle controlled study to assess the therapeutic"nefficacy and safety of Mice daily application of 1 pg/g and 5 fJ.g1g chalecakiferol. 1 pglg calcitriol and 50 Ilglg calcipotriol in /00 patients suffering from bilateral, symmetrical, moderate co severe plaque psoriasis was carried au!. Twice daily catcitriol and calcipotriol significantly improved erythema. thickness, seating an d global severity ofpsoriatic plaques, and was much more effective than vehicle (10% hard paraffin in white soft paraffin), but the diffua,ce ill clinical efficacy between cholecalciferol and vehicle was n()( statistically significant. all completion of study, clearance and marked improvement ofpsoriatic lesions was found in 4% of vitamin D 3 (1 /.1.glg) - treated, in 12% of vitamin D3 (5 !tglg) - treated, ill 48% of calcitriol (1/.1.glg)treated, and in 64% of calcipotriot (50 pglg) - treated. Mean sman levels of total calcium, albumin - adjusted total calcium, phosphorus, creatinine, and also mean values of a 24 h urine calcium, phosphorus. creatinine, an d mean urine calcium I creatinine ratio did not show clinically relevant changes in the baseline I end - point analysis. We conclude that topical . catcimol and calcipotrio! are effective and safe for the treamlau of plaque psoriasis.