Effects of Flow Rate on Mesenchymal Stem Cell Oxygen Consumption Rates in 3D Bone-Tissue-Engineered Constructs Cultured in Perfusion Bioreactor Systems

Effects of Flow Rate on Mesenchymal Stem Cell Oxygen Consumption Rates in 3D Bone-Tissue-Engineered Constructs Cultured in Perfusion Bioreactor Systems

Bone grafts represent a multibillion-dollar industry, with over a million grafts occurring each year. Common graft types are associated with issues such as donor site morbidity in autologous grafts and immunological response in allogenic grafts. Bone-tissue-engineered constructs are a logical approa...

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Bibliographic Details
Main Authors: Michael L. Felder, Aaron D. Simmons, Robert L. Shambaugh, Vassilios I. Sikavitsas
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Fluids
Subjects:
bioreactor
mesenchymal stem cell
flow perfusion
oxygen
real-time monitoring
residence time analysis
Online Access:https://www.mdpi.com/2311-5521/5/1/30

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