Deciphering the Molecular Recognition Mechanism of Multidrug Resistance <i>Staphylococcus aureus</i> NorA Efflux Pump Using a Supervised Molecular Dynamics Approach

Deciphering the Molecular Recognition Mechanism of Multidrug Resistance <i>Staphylococcus aureus</i> NorA Efflux Pump Using a Supervised Molecular Dynamics Approach

The use and misuse of antibiotics has resulted in critical conditions for drug-resistant bacteria emergency, accelerating the development of antimicrobial resistance (AMR). In this context, the co-administration of an antibiotic with a compound able to restore sufficient antibacterial activity may b...

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Bibliographic Details
Main Authors: Deborah Palazzotti, Maicol Bissaro, Giovanni Bolcato, Andrea Astolfi, Tommaso Felicetti, Stefano Sabatini, Mattia Sturlese, Violetta Cecchetti, Maria Letizia Barreca, Stefano Moro
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
antimicrobial resistance
norA efflux pump
homology modeling
molecular dynamics simulation
supervised molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/20/16/4041

Internet

https://www.mdpi.com/1422-0067/20/16/4041

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