Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal.

Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal.

Activation of signal transducer and activator of transcription 3 (STAT3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC) self-renewal. Our previous study showed that trans-acting transcription factor 5 (Sp5), an LIF/STAT3 downstream target, supports mESC self-renewal....

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Bibliographic Details
Main Authors: Ling Tang, Manman Wang, Dahai Liu, Mengting Gong, Qi-Long Ying, Shoudong Ye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5621696?pdf=render

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http://europepmc.org/articles/PMC5621696?pdf=render

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