Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future"

Evolution of bacteria towards resistance to antimicrobial drugs, including multidrug resistance, is unavoidable because it represents a particular aspect of the general evolution of bacteria that is unstoppable. Therefore, the only means of dealing with this situation is to delay the emergence and s...

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Main Author:	Patrice Courvalin
Format:	Article
Language:	English
Published:	Centers for Disease Control and Prevention 2005-10-01
Series:	Emerging Infectious Diseases
Subjects:	antimicrobial drugs antibiotics resistance evolution
Online Access:	https://wwwnc.cdc.gov/eid/article/11/10/05-1014_article

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spelling	doaj-d799903a92e84cc1bbf01bdc52f269e42020-11-25T02:34:00ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592005-10-0111101503150610.3201/eid1110.051014Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future"Patrice CourvalinEvolution of bacteria towards resistance to antimicrobial drugs, including multidrug resistance, is unavoidable because it represents a particular aspect of the general evolution of bacteria that is unstoppable. Therefore, the only means of dealing with this situation is to delay the emergence and subsequent dissemination of resistant bacteria or resistance genes. Resistance to antimicrobial drugs in bacteria can result from mutations in housekeeping structural or regulatory genes. Alternatively, resistance can result from the horizontal acquisition of foreign genetic information. The 2 phenomena are not mutually exclusive and can be associated in the emergence and more efficient spread of resistance. This review discusses the predictable future of the relationship between antimicrobial drugs and bacteria.https://wwwnc.cdc.gov/eid/article/11/10/05-1014_articleantimicrobial drugsantibioticsresistanceevolution
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Patrice Courvalin
spellingShingle	Patrice Courvalin Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future" Emerging Infectious Diseases antimicrobial drugs antibiotics resistance evolution
author_facet	Patrice Courvalin
author_sort	Patrice Courvalin
title	Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future"
title_short	Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future"
title_full	Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future"
title_fullStr	Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future"
title_full_unstemmed	Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future"
title_sort	antimicrobial drug resistance: "prediction is very difficult, especially about the future"
publisher	Centers for Disease Control and Prevention
series	Emerging Infectious Diseases
issn	1080-6040 1080-6059
publishDate	2005-10-01
description	Evolution of bacteria towards resistance to antimicrobial drugs, including multidrug resistance, is unavoidable because it represents a particular aspect of the general evolution of bacteria that is unstoppable. Therefore, the only means of dealing with this situation is to delay the emergence and subsequent dissemination of resistant bacteria or resistance genes. Resistance to antimicrobial drugs in bacteria can result from mutations in housekeeping structural or regulatory genes. Alternatively, resistance can result from the horizontal acquisition of foreign genetic information. The 2 phenomena are not mutually exclusive and can be associated in the emergence and more efficient spread of resistance. This review discusses the predictable future of the relationship between antimicrobial drugs and bacteria.
topic	antimicrobial drugs antibiotics resistance evolution
url	https://wwwnc.cdc.gov/eid/article/11/10/05-1014_article
work_keys_str_mv	AT patricecourvalin antimicrobialdrugresistancepredictionisverydifficultespeciallyaboutthefuture
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Antimicrobial Drug Resistance: "Prediction Is Very Difficult, Especially about the Future"

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