Spatiotemporal Gradient and Instability of Wnt Induce Heterogeneous Growth and Differentiation of Human Intestinal Organoids

Spatiotemporal Gradient and Instability of Wnt Induce Heterogeneous Growth and Differentiation of Human Intestinal Organoids

Summary: In a conventional culture of three-dimensional human intestinal organoids, extracellular matrix hydrogel has been used to provide a physical space for the growth and morphogenesis of organoids in the presence of exogenous morphogens such as Wnt3a. We found that organoids embedded in a dome-...

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Bibliographic Details
Main Authors: Woojung Shin, Alexander Wu, Soyoun Min, Yong Cheol Shin, R. Y. Declan Fleming, S. Gail Eckhardt, Hyun Jung Kim
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Cancer
Computer Modeling
Tissue Engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305605

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