Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes

Chronic obstructive pulmonary disease (COPD) can be associated with systemic inflammatory trademarks and can coexist with other chronic debilitating diseases such as osteoporosis, which is considered among the most serious comorbidities of COPD. In this review, we aimed at finding answers for the fo...

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Main Authors: Ahmad Naoras Bitar, Syed Azhar Syed Sulaiman, Irfhan Ali Hyder Ali, Irfanullah Khan, Amer Hayat Khan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2019;volume=11;issue=4;spage=310;epage=320;aulast=Bitar
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spelling doaj-d786114e7751492e9576e44ef639bfc12020-11-24T21:47:47ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062019-01-0111431032010.4103/jpbs.JPBS_126_19Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomesAhmad Naoras BitarSyed Azhar Syed SulaimanIrfhan Ali Hyder AliIrfanullah KhanAmer Hayat KhanChronic obstructive pulmonary disease (COPD) can be associated with systemic inflammatory trademarks and can coexist with other chronic debilitating diseases such as osteoporosis, which is considered among the most serious comorbidities of COPD. In this review, we aimed at finding answers for the following questions and tried to encapsulate the available literature: (1) how prevalent is osteoporosis among patients with COPD? (2) What are severity patterns of osteoporosis in case of COPD? (3) What are the therapeutic outcomes for patients with osteoporotic COPD? The total number of patients with COPD from all studies was 3815, majority of which were male (2658) representing 69.67% of patients. The mean ± standard deviation for percentage of forced expiratory volume in 1s (FEV1%) was 55.43 ± 14.62%, body mass index for almost 91.29% of patients was 24.4 ± 4.45 kg/m2, whereas fat-free mass index (FFMI) was 17 ± 0.93 kg/m2 for 17.66%. The percentage of patients with COPD having osteoporosis varied in the analyzed studies from 14% up to 66.6%. The mean prevalence of reported osteopenia from 14 studies (n = 2107) was 39.91%, whereas for osteoporosis, the mean prevalence was 37.62% for all included studies. Osteoporosis was highly prevalent among patients with COPD. It is reasonable to call for osteoporosis screening in patients with COPD who are above 65 years, in advanced stages, with BMI lower than 21 kg/m2 or with FFMI lower than 16 kg/m2 for males and 15 kg/m2 for females. There is a lack of research investigating severity and treatments of osteoporosis in patients with COPD.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2019;volume=11;issue=4;spage=310;epage=320;aulast=BitarBone mineral densitychronic obstructive pulmonary diseasedual-energy X-ray absorptiometryosteoporosissystematicmeta-analysis
collection DOAJ
language English
format Article
sources DOAJ
author Ahmad Naoras Bitar
Syed Azhar Syed Sulaiman
Irfhan Ali Hyder Ali
Irfanullah Khan
Amer Hayat Khan
spellingShingle Ahmad Naoras Bitar
Syed Azhar Syed Sulaiman
Irfhan Ali Hyder Ali
Irfanullah Khan
Amer Hayat Khan
Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes
Journal of Pharmacy and Bioallied Sciences
Bone mineral density
chronic obstructive pulmonary disease
dual-energy X-ray absorptiometry
osteoporosis
systematic
meta-analysis
author_facet Ahmad Naoras Bitar
Syed Azhar Syed Sulaiman
Irfhan Ali Hyder Ali
Irfanullah Khan
Amer Hayat Khan
author_sort Ahmad Naoras Bitar
title Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes
title_short Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes
title_full Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes
title_fullStr Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes
title_full_unstemmed Osteoporosis among patients with chronic obstructive pulmonary disease: Systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes
title_sort osteoporosis among patients with chronic obstructive pulmonary disease: systematic review and meta-analysis of prevalence, severity, and therapeutic outcomes
publisher Wolters Kluwer Medknow Publications
series Journal of Pharmacy and Bioallied Sciences
issn 0975-7406
publishDate 2019-01-01
description Chronic obstructive pulmonary disease (COPD) can be associated with systemic inflammatory trademarks and can coexist with other chronic debilitating diseases such as osteoporosis, which is considered among the most serious comorbidities of COPD. In this review, we aimed at finding answers for the following questions and tried to encapsulate the available literature: (1) how prevalent is osteoporosis among patients with COPD? (2) What are severity patterns of osteoporosis in case of COPD? (3) What are the therapeutic outcomes for patients with osteoporotic COPD? The total number of patients with COPD from all studies was 3815, majority of which were male (2658) representing 69.67% of patients. The mean ± standard deviation for percentage of forced expiratory volume in 1s (FEV1%) was 55.43 ± 14.62%, body mass index for almost 91.29% of patients was 24.4 ± 4.45 kg/m2, whereas fat-free mass index (FFMI) was 17 ± 0.93 kg/m2 for 17.66%. The percentage of patients with COPD having osteoporosis varied in the analyzed studies from 14% up to 66.6%. The mean prevalence of reported osteopenia from 14 studies (n = 2107) was 39.91%, whereas for osteoporosis, the mean prevalence was 37.62% for all included studies. Osteoporosis was highly prevalent among patients with COPD. It is reasonable to call for osteoporosis screening in patients with COPD who are above 65 years, in advanced stages, with BMI lower than 21 kg/m2 or with FFMI lower than 16 kg/m2 for males and 15 kg/m2 for females. There is a lack of research investigating severity and treatments of osteoporosis in patients with COPD.
topic Bone mineral density
chronic obstructive pulmonary disease
dual-energy X-ray absorptiometry
osteoporosis
systematic
meta-analysis
url http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2019;volume=11;issue=4;spage=310;epage=320;aulast=Bitar
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