Correlation between IL 6 level and syetem-complications following multiple trauma in patients with blunt abdominal injuries

• Main Authors: Gregorić Pavle D., Bajec Đorđe D., Šijački Ana D., Karadžić Borivoje A.
• Format: Article
• Language: English
• Published: Serbian Medical Society 2003-01-01
• Series: Srpski Arhiv za Celokupno Lekarstvo
• Subjects: multiple trauma; blunt abdominal trauma; Interleukin-6; complications
• Online Access: http://www.doiserbia.nb.rs/img/doi/0370-8179/2003/0370-81790304118G.pdf

Severe trauma is the third cause of death and the first one in the most vital and young population. In USA more children die of trauma then of all other causes. Blunt abdominal trauma takes 56 % cases of multiple traumas of all etiologies. Among multiple injured patients, near to 50 % have some system-complications, more of 60 % in the group of critically injured (ISS>35). Cytokines play the main role in the inflammatory reaction during the early phase response on trauma. Their secretion predicts system-complications as ARDS, SIRS, even MODS. Hypothetically, level of concentration of Interleukin-6 (IL 6) can improve methods of early diagnostic procedures for detecting SIRS and MODS, when scores are still low (preclinical level), at which stages therapy is more powerful and also cheaper. This prospective study includes 35 multiple injured persons with blunt abdominal trauma (75>ISS>18). We have used standard diagnostic procedures. Concentration of IL 6 was detected with ELISA-test. Levels of IL 6 were significantly higher in correlation with SIRS score groups. Correlation with MODS score was not significant for the lowest scores, but IL 6 showed significant higher levels in the second and the third MODS score group.