Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.

Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.

Chemotherapy resistance is the major reason for the failure of ovarian cancer treatment. One mechanism behind chemo-resistance involves the upregulation of multidrug resistance (MDR) genes (ABC transporters) that effectively transport (efflux) drugs out of the tumor cells. As a common symptom in sta...

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Bibliographic Details
Main Authors: Lihong Mo, Vendula Pospichalova, Zhiqing Huang, Susan K Murphy, Sturgis Payne, Fang Wang, Margaret Kennedy, George J Cianciolo, Vitezslav Bryja, Salvatore V Pizzo, Robin E Bachelder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4493087?pdf=render

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