Trainable high resolution melt curve machine learning classifier for large-scale reliable genotyping of sequence variants.

Trainable high resolution melt curve machine learning classifier for large-scale reliable genotyping of sequence variants.

High resolution melt (HRM) is gaining considerable popularity as a simple and robust method for genotyping sequence variants. However, accurate genotyping of an unknown sample for which a large number of possible variants may exist will require an automated HRM curve identification method capable of...

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Bibliographic Details
Main Authors: Pornpat Athamanolap, Vishwa Parekh, Stephanie I Fraley, Vatsal Agarwal, Dong J Shin, Michael A Jacobs, Tza-Huei Wang, Samuel Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4183555?pdf=render

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