Shedding new light on circadian clocks

Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains.

Bibliographic Details
Main Authors: Maud Demarque, Ueli Schibler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/00659
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spelling doaj-d762a89dbfc2400fad4ca5686fb1042f2021-05-04T22:25:56ZengeLife Sciences Publications LtdeLife2050-084X2013-04-01210.7554/eLife.00659Shedding new light on circadian clocksMaud Demarque0Ueli Schibler1Department of Molecular Biology, University of Geneva, Geneva, Switzerlandthe Department of Molecular Biology, University of Geneva, Geneva, SwitzerlandUsing a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains.https://elifesciences.org/articles/00659Clock geneUSF1genetic modifiercircadian rhythmmouse geneticChIP-Seq
collection DOAJ
language English
format Article
sources DOAJ
author Maud Demarque
Ueli Schibler
spellingShingle Maud Demarque
Ueli Schibler
Shedding new light on circadian clocks
eLife
Clock gene
USF1
genetic modifier
circadian rhythm
mouse genetic
ChIP-Seq
author_facet Maud Demarque
Ueli Schibler
author_sort Maud Demarque
title Shedding new light on circadian clocks
title_short Shedding new light on circadian clocks
title_full Shedding new light on circadian clocks
title_fullStr Shedding new light on circadian clocks
title_full_unstemmed Shedding new light on circadian clocks
title_sort shedding new light on circadian clocks
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2013-04-01
description Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains.
topic Clock gene
USF1
genetic modifier
circadian rhythm
mouse genetic
ChIP-Seq
url https://elifesciences.org/articles/00659
work_keys_str_mv AT mauddemarque sheddingnewlightoncircadianclocks
AT uelischibler sheddingnewlightoncircadianclocks
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