The First Case of Ischemia-Free Kidney Transplantation in Humans
Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the fir...
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2019.00276/full |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiaoshun He Xiaoshun He Xiaoshun He Guodong Chen Guodong Chen Guodong Chen Zebin Zhu Zebin Zhu Zebin Zhu Zhiheng Zhang Zhiheng Zhang Zhiheng Zhang Xiaopeng Yuan Xiaopeng Yuan Xiaopeng Yuan Ming Han Ming Han Ming Han Qiang Zhao Qiang Zhao Qiang Zhao Yitao Zheng Yitao Zheng Yitao Zheng Yunhua Tang Yunhua Tang Yunhua Tang Shanzhou Huang Shanzhou Huang Shanzhou Huang Linhe Wang Linhe Wang Linhe Wang Otto B. van Leeuwen Xiaoping Wang Xiaoping Wang Xiaoping Wang Chuanbao Chen Chuanbao Chen Chuanbao Chen Liqiu Mo Xingyuan Jiao Xingyuan Jiao Xingyuan Jiao Xianchang Li Xianchang Li Xianchang Li Xianchang Li Changxi Wang Changxi Wang Changxi Wang Jiefu Huang Jiefu Huang Jun Cui Zhiyong Guo Zhiyong Guo Zhiyong Guo |
| spellingShingle |
Xiaoshun He Xiaoshun He Xiaoshun He Guodong Chen Guodong Chen Guodong Chen Zebin Zhu Zebin Zhu Zebin Zhu Zhiheng Zhang Zhiheng Zhang Zhiheng Zhang Xiaopeng Yuan Xiaopeng Yuan Xiaopeng Yuan Ming Han Ming Han Ming Han Qiang Zhao Qiang Zhao Qiang Zhao Yitao Zheng Yitao Zheng Yitao Zheng Yunhua Tang Yunhua Tang Yunhua Tang Shanzhou Huang Shanzhou Huang Shanzhou Huang Linhe Wang Linhe Wang Linhe Wang Otto B. van Leeuwen Xiaoping Wang Xiaoping Wang Xiaoping Wang Chuanbao Chen Chuanbao Chen Chuanbao Chen Liqiu Mo Xingyuan Jiao Xingyuan Jiao Xingyuan Jiao Xianchang Li Xianchang Li Xianchang Li Xianchang Li Changxi Wang Changxi Wang Changxi Wang Jiefu Huang Jiefu Huang Jun Cui Zhiyong Guo Zhiyong Guo Zhiyong Guo The First Case of Ischemia-Free Kidney Transplantation in Humans Frontiers in Medicine kidney transplantation ischemia-reperfusion injury normothermic machine perfusion ischemia-free kidney transplantation ischemia-free organ transplantation |
| author_facet |
Xiaoshun He Xiaoshun He Xiaoshun He Guodong Chen Guodong Chen Guodong Chen Zebin Zhu Zebin Zhu Zebin Zhu Zhiheng Zhang Zhiheng Zhang Zhiheng Zhang Xiaopeng Yuan Xiaopeng Yuan Xiaopeng Yuan Ming Han Ming Han Ming Han Qiang Zhao Qiang Zhao Qiang Zhao Yitao Zheng Yitao Zheng Yitao Zheng Yunhua Tang Yunhua Tang Yunhua Tang Shanzhou Huang Shanzhou Huang Shanzhou Huang Linhe Wang Linhe Wang Linhe Wang Otto B. van Leeuwen Xiaoping Wang Xiaoping Wang Xiaoping Wang Chuanbao Chen Chuanbao Chen Chuanbao Chen Liqiu Mo Xingyuan Jiao Xingyuan Jiao Xingyuan Jiao Xianchang Li Xianchang Li Xianchang Li Xianchang Li Changxi Wang Changxi Wang Changxi Wang Jiefu Huang Jiefu Huang Jun Cui Zhiyong Guo Zhiyong Guo Zhiyong Guo |
| author_sort |
Xiaoshun He |
| title |
The First Case of Ischemia-Free Kidney Transplantation in Humans |
| title_short |
The First Case of Ischemia-Free Kidney Transplantation in Humans |
| title_full |
The First Case of Ischemia-Free Kidney Transplantation in Humans |
| title_fullStr |
The First Case of Ischemia-Free Kidney Transplantation in Humans |
| title_full_unstemmed |
The First Case of Ischemia-Free Kidney Transplantation in Humans |
| title_sort |
first case of ischemia-free kidney transplantation in humans |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Medicine |
| issn |
2296-858X |
| publishDate |
2019-12-01 |
| description |
Background: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT).Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion.Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery.Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation. |
| topic |
kidney transplantation ischemia-reperfusion injury normothermic machine perfusion ischemia-free kidney transplantation ischemia-free organ transplantation |
| url |
https://www.frontiersin.org/article/10.3389/fmed.2019.00276/full |
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doaj-d75b802f802b49858b78460daf3ac1ef2020-11-25T01:46:42ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2019-12-01610.3389/fmed.2019.00276489563The First Case of Ischemia-Free Kidney Transplantation in HumansXiaoshun He0Xiaoshun He1Xiaoshun He2Guodong Chen3Guodong Chen4Guodong Chen5Zebin Zhu6Zebin Zhu7Zebin Zhu8Zhiheng Zhang9Zhiheng Zhang10Zhiheng Zhang11Xiaopeng Yuan12Xiaopeng Yuan13Xiaopeng Yuan14Ming Han15Ming Han16Ming Han17Qiang Zhao18Qiang Zhao19Qiang Zhao20Yitao Zheng21Yitao Zheng22Yitao Zheng23Yunhua Tang24Yunhua Tang25Yunhua Tang26Shanzhou Huang27Shanzhou Huang28Shanzhou Huang29Linhe Wang30Linhe Wang31Linhe Wang32Otto B. van Leeuwen33Xiaoping Wang34Xiaoping Wang35Xiaoping Wang36Chuanbao Chen37Chuanbao Chen38Chuanbao Chen39Liqiu Mo40Xingyuan Jiao41Xingyuan Jiao42Xingyuan Jiao43Xianchang Li44Xianchang Li45Xianchang Li46Xianchang Li47Changxi Wang48Changxi Wang49Changxi Wang50Jiefu Huang51Jiefu Huang52Jun Cui53Zhiyong Guo54Zhiyong Guo55Zhiyong Guo56Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, NetherlandsOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaDepartment of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaImmunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX, United StatesOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaPeking Union Medical College Hospital, Beijing, ChinaMOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Guangzhou, ChinaGuangdong Provincial International Cooperation Base of Science and Technology (Organ Transplantation), Guangzhou, ChinaBackground: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid IRI, we have established a novel procedure called ischemia-free organ transplantation. Here, we describe the first case of ischemia-free kidney transplantation (IFKT).Materials and Methods: The kidney graft was donated by a 19-year-old brain-dead donor. The recipient was a 47-year-old man with end-stage diabetic nephropathy. The graft was procured, preserved, and implanted without cessation of blood supply using normothermic machine perfusion.Results: The graft appearance, perfusion flow, and urine production suggested that the kidney was functioning well-during the whole procedure. The creatinine dropped rapidly to normal range within 3 days post-transplantation. The levels of serum renal injury markers were low post-transplantation. No rejection or vascular or infectious complications occurred. The patient had an uneventful recovery.Conclusion: This paper marks the first case of IFKT in humans. This innovation may offer a unique solution to optimizing transplant outcomes in kidney transplantation.https://www.frontiersin.org/article/10.3389/fmed.2019.00276/fullkidney transplantationischemia-reperfusion injurynormothermic machine perfusionischemia-free kidney transplantationischemia-free organ transplantation |