Revealing Different Roles of the mTOR-Targets S6K1 and S6K2 in Breast Cancer by Expression Profiling and Structural Analysis.

Revealing Different Roles of the mTOR-Targets S6K1 and S6K2 in Breast Cancer by Expression Profiling and Structural Analysis.

BACKGROUND:The AKT/mTORC1/S6K pathway is frequently overstimulated in breast cancer, constituting a promising therapeutic target. The benefit from mTOR inhibitors varies, likely as a consequence of tumour heterogeneity, and upregulation of several compensatory feed-back mechanisms. The mTORC1 downst...

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Bibliographic Details
Main Authors: Elin Karlsson, Ivana Magić, Josefine Bostner, Christine Dyrager, Fredrik Lysholm, Anna-Lotta Hallbeck, Olle Stål, Patrik Lundström
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4689523?pdf=render

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http://europepmc.org/articles/PMC4689523?pdf=render

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