Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma

Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma

The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV− tumors represent two unique biological and clinical entities with different treatment strategies. H...

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Main Authors: Katherine C. Wai, Madeleine P. Strohl, Annemieke van Zante, Patrick K. Ha
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
human papillomavirus (hpv)
head and neck cancer
p16
Online Access:https://www.mdpi.com/2073-4409/9/2/500
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spelling doaj-d73bcfe99b8a4d339558b6f0d40d63bd2020-11-25T03:01:10ZengMDPI AGCells2073-44092020-02-019250010.3390/cells9020500cells9020500Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell CarcinomaKatherine C. Wai0Madeleine P. Strohl1Annemieke van Zante2Patrick K. Ha3Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94158, USADepartment of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94158, USADepartment of Pathology, University of California San Francisco, San Francisco, CA 94158, USADepartment of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94158, USAThe incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV− tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode oncoproteins E6 and E7 that disrupt cellular senescence and ultimately drive tumorigenesis. Current methods for detection of HPV take advantage of this established oncogenic pathway and detect HPV at various biological stages. This review article provides an overview of the existing technologies employed for the detection of HPV and their current or potential future role in management and prognostication.https://www.mdpi.com/2073-4409/9/2/500human papillomavirus (hpv)head and neck cancerp16
collection DOAJ
language English
format Article
sources DOAJ
author Katherine C. Wai
Madeleine P. Strohl
Annemieke van Zante
Patrick K. Ha
spellingShingle Katherine C. Wai
Madeleine P. Strohl
Annemieke van Zante
Patrick K. Ha
Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma
Cells
human papillomavirus (hpv)
head and neck cancer
p16
author_facet Katherine C. Wai
Madeleine P. Strohl
Annemieke van Zante
Patrick K. Ha
author_sort Katherine C. Wai
title Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma
title_short Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma
title_full Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma
title_fullStr Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma
title_full_unstemmed Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma
title_sort molecular diagnostics in human papillomavirus-related head and neck squamous cell carcinoma
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-02-01
description The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV− tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode oncoproteins E6 and E7 that disrupt cellular senescence and ultimately drive tumorigenesis. Current methods for detection of HPV take advantage of this established oncogenic pathway and detect HPV at various biological stages. This review article provides an overview of the existing technologies employed for the detection of HPV and their current or potential future role in management and prognostication.
topic human papillomavirus (hpv)
head and neck cancer
p16
url https://www.mdpi.com/2073-4409/9/2/500
work_keys_str_mv AT katherinecwai moleculardiagnosticsinhumanpapillomavirusrelatedheadandnecksquamouscellcarcinoma
AT madeleinepstrohl moleculardiagnosticsinhumanpapillomavirusrelatedheadandnecksquamouscellcarcinoma
AT annemiekevanzante moleculardiagnosticsinhumanpapillomavirusrelatedheadandnecksquamouscellcarcinoma
AT patrickkha moleculardiagnosticsinhumanpapillomavirusrelatedheadandnecksquamouscellcarcinoma
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