White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease

We explored parameters to predicting the efficacy of intravenous immunoglobulin (IVIG) therapy for patients with Kawasaki disease (KD). We retrospectively analyzed the laboratory data of 77 children with KD treated with IVIG. Data obtained before and within 24 hours after IVIG therapy were compared...

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Main Authors:	Taichiro Muto MD, PhD, Yu Masuda MD, Shingo Numoto MD, Shunsuke Kodama MD, Kiyoshi Yamakawa MD, Michihiko Takasu MD, Tomohito Hayakawa MD, Kenji Miyata MD, Ryosuke Miyamoto MD, Mitsuko Akaihata MD, Hideyuki Iwayama MD, PhD, Yoshiro Kitagawa MD, PhD, Hirokazu Kurahashi MD, PhD, Yasuto Shimomura MD, PhD, Toshinori Hori MD, PhD, Masumi Okuda MD, PhD, Hiroatsu Agata MD, PhD, Akihisa Okumura MD, PhD
Format:	Article
Language:	English
Published:	SAGE Publishing 2019-10-01
Series:	Global Pediatric Health
Online Access:	https://doi.org/10.1177/2333794X19884826

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spelling	doaj-d7331f7615eb485a9c270aa3b09333892020-11-25T03:31:09ZengSAGE PublishingGlobal Pediatric Health2333-794X2019-10-01610.1177/2333794X19884826White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki DiseaseTaichiro Muto MD, PhD0Yu Masuda MD1Shingo Numoto MD2Shunsuke Kodama MD3Kiyoshi Yamakawa MD4Michihiko Takasu MD5Tomohito Hayakawa MD6Kenji Miyata MD7Ryosuke Miyamoto MD8Mitsuko Akaihata MD9Hideyuki Iwayama MD, PhD10Yoshiro Kitagawa MD, PhD11Hirokazu Kurahashi MD, PhD12Yasuto Shimomura MD, PhD13Toshinori Hori MD, PhD14Masumi Okuda MD, PhD15Hiroatsu Agata MD, PhD16Akihisa Okumura MD, PhD17Aichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanAichi Medical University, Nagakute, Aichi, JapanWe explored parameters to predicting the efficacy of intravenous immunoglobulin (IVIG) therapy for patients with Kawasaki disease (KD). We retrospectively analyzed the laboratory data of 77 children with KD treated with IVIG. Data obtained before and within 24 hours after IVIG therapy were compared between responders and nonresponders. The white blood cell (WBC) and neutrophil counts were significantly lower in responders than nonresponders within 24 hours after IVIG. The areas under the receiver operating characteristics curves of the WBC and neutrophil counts were 0.846 and 0.754, respectively. The WBC and neutrophil counts differed significantly between responders and nonresponders (the latter developed recurrent pyrexia after transient fever resolution). In conclusion, WBC and neutrophil counts within 24 hours after IVIG usefully predict the efficacy of IVIG therapy for those with KD, and identify nonresponders to such therapy.https://doi.org/10.1177/2333794X19884826
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Taichiro Muto MD, PhD Yu Masuda MD Shingo Numoto MD Shunsuke Kodama MD Kiyoshi Yamakawa MD Michihiko Takasu MD Tomohito Hayakawa MD Kenji Miyata MD Ryosuke Miyamoto MD Mitsuko Akaihata MD Hideyuki Iwayama MD, PhD Yoshiro Kitagawa MD, PhD Hirokazu Kurahashi MD, PhD Yasuto Shimomura MD, PhD Toshinori Hori MD, PhD Masumi Okuda MD, PhD Hiroatsu Agata MD, PhD Akihisa Okumura MD, PhD
spellingShingle	Taichiro Muto MD, PhD Yu Masuda MD Shingo Numoto MD Shunsuke Kodama MD Kiyoshi Yamakawa MD Michihiko Takasu MD Tomohito Hayakawa MD Kenji Miyata MD Ryosuke Miyamoto MD Mitsuko Akaihata MD Hideyuki Iwayama MD, PhD Yoshiro Kitagawa MD, PhD Hirokazu Kurahashi MD, PhD Yasuto Shimomura MD, PhD Toshinori Hori MD, PhD Masumi Okuda MD, PhD Hiroatsu Agata MD, PhD Akihisa Okumura MD, PhD White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease Global Pediatric Health
author_facet	Taichiro Muto MD, PhD Yu Masuda MD Shingo Numoto MD Shunsuke Kodama MD Kiyoshi Yamakawa MD Michihiko Takasu MD Tomohito Hayakawa MD Kenji Miyata MD Ryosuke Miyamoto MD Mitsuko Akaihata MD Hideyuki Iwayama MD, PhD Yoshiro Kitagawa MD, PhD Hirokazu Kurahashi MD, PhD Yasuto Shimomura MD, PhD Toshinori Hori MD, PhD Masumi Okuda MD, PhD Hiroatsu Agata MD, PhD Akihisa Okumura MD, PhD
author_sort	Taichiro Muto MD, PhD
title	White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease
title_short	White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease
title_full	White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease
title_fullStr	White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease
title_full_unstemmed	White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease
title_sort	white blood cell and neutrophil counts and response to intravenous immunoglobulin in kawasaki disease
publisher	SAGE Publishing
series	Global Pediatric Health
issn	2333-794X
publishDate	2019-10-01
description	We explored parameters to predicting the efficacy of intravenous immunoglobulin (IVIG) therapy for patients with Kawasaki disease (KD). We retrospectively analyzed the laboratory data of 77 children with KD treated with IVIG. Data obtained before and within 24 hours after IVIG therapy were compared between responders and nonresponders. The white blood cell (WBC) and neutrophil counts were significantly lower in responders than nonresponders within 24 hours after IVIG. The areas under the receiver operating characteristics curves of the WBC and neutrophil counts were 0.846 and 0.754, respectively. The WBC and neutrophil counts differed significantly between responders and nonresponders (the latter developed recurrent pyrexia after transient fever resolution). In conclusion, WBC and neutrophil counts within 24 hours after IVIG usefully predict the efficacy of IVIG therapy for those with KD, and identify nonresponders to such therapy.
url	https://doi.org/10.1177/2333794X19884826
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White Blood Cell and Neutrophil Counts and Response to Intravenous Immunoglobulin in Kawasaki Disease

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