Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse

Abstract The human turbinate-derived mesenchymal stem cells (hTMSCs), which were DiI-labeled and transplanted into the subretinal space in degenerating mouse retina, were observed in retinal vertical sections processed for rhodopsin (a marker for rod photoreceptor) by confocal microscope with differ...

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Main Authors:	Yong Soo Park, Yeonji Kim, Sung Won Kim, In-Beom Kim
Format:	Article
Language:	English
Published:	SpringerOpen 2020-06-01
Series:	Applied Microscopy
Subjects:	Human turbinate-derived mesenchymal stem cell Rod photoreceptor Retinal degeneration Confocal microscope Differential interference contrast
Online Access:	https://doi.org/10.1186/s42649-020-00031-w

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spelling	doaj-d7304f498c45429f9d5f95ce1687e67e2021-06-06T11:29:00ZengSpringerOpenApplied Microscopy2287-44452020-06-015011310.1186/s42649-020-00031-wLight microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouseYong Soo Park0Yeonji Kim1Sung Won Kim2In-Beom Kim3Department of Anatomy, College of Medicine, The Catholic University of KoreaDepartment of Anatomy, College of Medicine, The Catholic University of KoreaDepartment of Otolaryngology-Head and Neck Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Anatomy, College of Medicine, The Catholic University of KoreaAbstract The human turbinate-derived mesenchymal stem cells (hTMSCs), which were DiI-labeled and transplanted into the subretinal space in degenerating mouse retina, were observed in retinal vertical sections processed for rhodopsin (a marker for rod photoreceptor) by confocal microscope with differential interference contrast (DIC) filters. The images clearly demonstrated that DiI-labeled hTMSCs have rhodopsin-immunoreactive appendages, indicating differentiation of transplanted hTMSC into rod photoreceptor. Conclusively, the finding suggests therapeutic potential of hTMSCs in retinal degeneration.https://doi.org/10.1186/s42649-020-00031-wHuman turbinate-derived mesenchymal stem cellRod photoreceptorRetinal degenerationConfocal microscopeDifferential interference contrast
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yong Soo Park Yeonji Kim Sung Won Kim In-Beom Kim
spellingShingle	Yong Soo Park Yeonji Kim Sung Won Kim In-Beom Kim Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse Applied Microscopy Human turbinate-derived mesenchymal stem cell Rod photoreceptor Retinal degeneration Confocal microscope Differential interference contrast
author_facet	Yong Soo Park Yeonji Kim Sung Won Kim In-Beom Kim
author_sort	Yong Soo Park
title	Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse
title_short	Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse
title_full	Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse
title_fullStr	Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse
title_full_unstemmed	Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse
title_sort	light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse
publisher	SpringerOpen
series	Applied Microscopy
issn	2287-4445
publishDate	2020-06-01
description	Abstract The human turbinate-derived mesenchymal stem cells (hTMSCs), which were DiI-labeled and transplanted into the subretinal space in degenerating mouse retina, were observed in retinal vertical sections processed for rhodopsin (a marker for rod photoreceptor) by confocal microscope with differential interference contrast (DIC) filters. The images clearly demonstrated that DiI-labeled hTMSCs have rhodopsin-immunoreactive appendages, indicating differentiation of transplanted hTMSC into rod photoreceptor. Conclusively, the finding suggests therapeutic potential of hTMSCs in retinal degeneration.
topic	Human turbinate-derived mesenchymal stem cell Rod photoreceptor Retinal degeneration Confocal microscope Differential interference contrast
url	https://doi.org/10.1186/s42649-020-00031-w
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Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse

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