Quality of Life of Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) and Stevens-Johnson Syndrome (SJS) and/or Toxic Epidermal Necrolysis (TEN) Patients

• Main Authors: Perwitasari DA, Febriana SA, Tristiana RS
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-02-01
• Series: Patient Preference and Adherence
• Subjects: dress; qol; sjs; ten; skin diseases
• Online Access: https://www.dovepress.com/quality-of-life-of-drug-reaction-with-eosinophilia-and-systemic-sympto-peer-reviewed-article-PPA

Dyah Aryani Perwitasari,1 Sri Awalia Febriana,2 Ratna Septi Tristiana1 1Faculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia; 2Department of Dermatology and Venereology, Universitas Gadjah Mada, Yogyakarta, IndonesiaCorrespondence: Dyah Aryani PerwitasariFaculty of Pharmacy, Universitas Ahmad Dahlan, Kampus 3 UAD, Jl Prof Dr Soepomo, Janturan, Yogyakarta, 55164, IndonesiaTel/Fax [phone]Email [e-mail]: Drug Reaction With Eosinophilia and Systemic Symptom (DRESS), Stevens-Johnson Syndrome (SJS), and Toxic Epidermal Necrolysis (TEN) are acute hypersensitivity reactions with the potential to reduce the quality of life of exposed individuals. This study aims to determine the quality of life of patients suffering from DRESS, SJS, SJS/TEN.Patients and Methods: A cross-sectional approach was used to get the quality of life data from DRESS, SJS, and/or TEN patients at Dr. Sardjito general hospital, Yogyakarta. The utility index and VAS score differences of EQ-5D-5L were analyzed based on the diagnosis.Results: We recruited 58 patients. Most of the patients were female (63%). The mean value of utility index was 0.61, 0.08 and 0.03 for DRESS, SJS and SJS/TEN patients, respectively (p value < 0.01). Furthermore, the mean of VAS score was 73.36, 57.93 and 50.00 for DRESS, SJS and SJS/TEN patients, respectively (p value < 0.01).Conclusion: In general, the quality of life of DRESS patients is better than the quality of life of SJS and/or TEN patients.Keywords: DRESS, QoL, SJS, TEN, skin diseases