VTET: a variable threshold exact test for identifying disease-associated copy number variations enriched in short genomic regions

VTET: a variable threshold exact test for identifying disease-associated copy number variations enriched in short genomic regions

Copy number variations (CNVs) constitute a major source of genetic variations in human populations and have been reported to be associated with complex diseases. Methods have been developed for detecting CNVs and testing CNV associations in genome-wide association studies (GWAS) based on SNP arrays....

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Bibliographic Details
Main Authors: Jianxin eShi, Xiaohong R. Yang, Neil eCaporaso, Maria Teresa Pia eLandi, Peng eLi
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Genetics
Subjects:
Genome-Wide Association Study
Copy number varination
variable threshold exact test
Interval-based association test
Lung cancer CNV analysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00053/full

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