Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms

Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms

Secondary active transporters are critical for neurotransmitter clearance and recycling during synaptic transmission and uptake of nutrients. These proteins mediate the movement of solutes against their concentration gradients, by using the energy released in the movement of ions down pre-existing c...

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Bibliographic Details
Main Authors: Cristina eFenollar Ferrer, Ariela eVergara Jaque, Desirée eKaufmann, Lucy Rachel Forrest
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Pharmacology
Subjects:
Glutamate
neurotransmitter
membrane protein
Secondary transport
alternating access
asymmetry exchange
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00183/full

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