Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease
Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the inner leaflet of membranes, and it is especially abundant in the inner mitochondrial membrane. PE has quite remarkable act...
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Hindawi Limited
2017-01-01
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| Series: | Oxidative Medicine and Cellular Longevity |
| Online Access: | http://dx.doi.org/10.1155/2017/4829180 |
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doaj-d70769fc2af141c0b88cce6ad1825bd72020-11-24T21:30:08ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942017-01-01201710.1155/2017/48291804829180Ethanolamine and Phosphatidylethanolamine: Partners in Health and DiseaseDhaval Patel0Stephan N. Witt1Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USADepartment of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USAPhosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the inner leaflet of membranes, and it is especially abundant in the inner mitochondrial membrane. PE has quite remarkable activities: it is a lipid chaperone that assists in the folding of certain membrane proteins, it is required for the activity of several of the respiratory complexes, and it plays a key role in the initiation of autophagy. In this review, we focus on PE’s roles in lipid-induced stress in the endoplasmic reticulum (ER), Parkinson’s disease (PD), ferroptosis, and cancer.http://dx.doi.org/10.1155/2017/4829180 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Dhaval Patel Stephan N. Witt |
| spellingShingle |
Dhaval Patel Stephan N. Witt Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease Oxidative Medicine and Cellular Longevity |
| author_facet |
Dhaval Patel Stephan N. Witt |
| author_sort |
Dhaval Patel |
| title |
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease |
| title_short |
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease |
| title_full |
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease |
| title_fullStr |
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease |
| title_full_unstemmed |
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease |
| title_sort |
ethanolamine and phosphatidylethanolamine: partners in health and disease |
| publisher |
Hindawi Limited |
| series |
Oxidative Medicine and Cellular Longevity |
| issn |
1942-0900 1942-0994 |
| publishDate |
2017-01-01 |
| description |
Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the inner leaflet of membranes, and it is especially abundant in the inner mitochondrial membrane. PE has quite remarkable activities: it is a lipid chaperone that assists in the folding of certain membrane proteins, it is required for the activity of several of the respiratory complexes, and it plays a key role in the initiation of autophagy. In this review, we focus on PE’s roles in lipid-induced stress in the endoplasmic reticulum (ER), Parkinson’s disease (PD), ferroptosis, and cancer. |
| url |
http://dx.doi.org/10.1155/2017/4829180 |
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AT dhavalpatel ethanolamineandphosphatidylethanolaminepartnersinhealthanddisease AT stephannwitt ethanolamineandphosphatidylethanolaminepartnersinhealthanddisease |
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