Intranasally administered protein coated chitosan nanoparticles encapsulating influenza H9N2 HA2 and M2e mRNA molecules elicit protective immunity against avian influenza viruses in chickens

Intranasally administered protein coated chitosan nanoparticles encapsulating influenza H9N2 HA2 and M2e mRNA molecules elicit protective immunity against avian influenza viruses in chickens

Abstract Chitosan nanoparticles (CNPs) represent an efficient vaccination tool to deliver immunogenic antigens to the antigen-presenting cells (APCs), which subsequently stimulate protective immune responses against infectious diseases. Herein, we prepared CNPs encapsulating mRNA molecules followed...

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Bibliographic Details
Main Authors: Irshad Ahmed Hajam, Amal Senevirathne, Chamit Hewawaduge, Jehyoung Kim, John Hwa Lee
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Veterinary Research
Online Access:http://link.springer.com/article/10.1186/s13567-020-00762-4

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