Roles, function and relevance of LAG3 in HIV infection.
HIV causes several forms of immune dysfunction that need to be addressed in a functional cure for HIV. Immune exhaustion describes a dysfunctional phenotype caused by chronic cellular activation. Lymphocyte activation gene-3 (LAG3) is one of several negative coreceptors known as immune checkpoints t...
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| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1007429 |
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doaj-d6ecdd821f1649c586564fe869f5902b2021-04-21T17:11:22ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742019-01-01151e100742910.1371/journal.ppat.1007429Roles, function and relevance of LAG3 in HIV infection.Colin G GraydonAllison L BalaskoKeith R FowkeHIV causes several forms of immune dysfunction that need to be addressed in a functional cure for HIV. Immune exhaustion describes a dysfunctional phenotype caused by chronic cellular activation. Lymphocyte activation gene-3 (LAG3) is one of several negative coreceptors known as immune checkpoints that contribute to this exhaustion phenotype. Antibodies targeting immune checkpoints are now used clinically to restore immunity against cancer and hold promise in restoring immunity during HIV infection. Here, we summarize current knowledge surrounding LAG3 and discuss its relevance during HIV infection and the potential for LAG3-targeting antibodies in a functional HIV cure.https://doi.org/10.1371/journal.ppat.1007429 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Colin G Graydon Allison L Balasko Keith R Fowke |
| spellingShingle |
Colin G Graydon Allison L Balasko Keith R Fowke Roles, function and relevance of LAG3 in HIV infection. PLoS Pathogens |
| author_facet |
Colin G Graydon Allison L Balasko Keith R Fowke |
| author_sort |
Colin G Graydon |
| title |
Roles, function and relevance of LAG3 in HIV infection. |
| title_short |
Roles, function and relevance of LAG3 in HIV infection. |
| title_full |
Roles, function and relevance of LAG3 in HIV infection. |
| title_fullStr |
Roles, function and relevance of LAG3 in HIV infection. |
| title_full_unstemmed |
Roles, function and relevance of LAG3 in HIV infection. |
| title_sort |
roles, function and relevance of lag3 in hiv infection. |
| publisher |
Public Library of Science (PLoS) |
| series |
PLoS Pathogens |
| issn |
1553-7366 1553-7374 |
| publishDate |
2019-01-01 |
| description |
HIV causes several forms of immune dysfunction that need to be addressed in a functional cure for HIV. Immune exhaustion describes a dysfunctional phenotype caused by chronic cellular activation. Lymphocyte activation gene-3 (LAG3) is one of several negative coreceptors known as immune checkpoints that contribute to this exhaustion phenotype. Antibodies targeting immune checkpoints are now used clinically to restore immunity against cancer and hold promise in restoring immunity during HIV infection. Here, we summarize current knowledge surrounding LAG3 and discuss its relevance during HIV infection and the potential for LAG3-targeting antibodies in a functional HIV cure. |
| url |
https://doi.org/10.1371/journal.ppat.1007429 |
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