Renal function and choroidal thickness using swept-source optical coherence tomography in diabetic patients

• Main Authors: Antonio Manuel Garrido-Hermosilla, Mariola Méndez-Muros, Estanislao Gutiérrez-Sánchez, Cristóbal Morales-Portillo, María Jesús Díaz-Granda, Eduardo Esteban-González, Isabel Relimpio-López, María Asunción Martínez-Brocca, Enrique Rodríguez-de-la-Rúa-Franch
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2019-06-01
• Series: International Journal of Ophthalmology
• Subjects: choroidal thickness; renal function; swept-source optical coherence tomography; spectral-domain optical coherence tomography; diabetes mellitus
• Online Access: http://www.ijo.cn/en_publish/2019/6/20190617.pdf

AIM: To assess the relationship between choroidal thickness and renal function in diabetic patients. METHODS: Cross-sectional retrospective clinical study of 42 eyes of 21 ocular treatment-naïve diabetic patients. Demographic data included: age, sex, type and course of diabetes. Ocular data included: severity of diabetic retinopathy; retinal thickness at the central macular region, as well as choroidal thickness at the central and paracentral quadrants, using automatically generated maps by swept-source optical coherence tomography; presence of cystic macular edema; and ocular axial length (AXL). Lab-test parameters included: glycated hemoglobin (HbA1c), albuminuria, albumin/creatinine ratio in urine, and glomerular filtration rate. RESULTS: A significant negative correlation was mainly observed between several choroidal thicknesses, age (P<0.020) and ocular AXL (P<0.030). On the contrary, a significant positive correlation was found between all choroidal thicknesses, HbA1c (P<0.035) and albuminuria (P<0.040). CONCLUSION: Choroidal thickness can represent an additional tool to help clinicians predicting the renal status in ocular treatment-naïve diabetic patients.