On detecting reference level of acrolein content in children's blood

• Main Authors: T.S. Ulanova, O.O. Sinitsyna, T.D. Karnazhitskaya, E.O. Zavernenkova
• Format: Article
• Language: English
• Published: FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies” 2017-03-01
• Series: Analiz Riska Zdorovʹû
• Subjects: acrolein; chronic exposure; response markers; blood; highly efficient liquid chromatography; delta-aminolevulinic acid; bilirubin; reference level
• Online Access: http://journal.fcrisk.ru/eng/2017/1/4
• ISSN: 2308-1155; 2308-1163

The article gives the results of complex chemical-analytical and clinical-laboratory research in course of which biological media of children living in Perm region were examined. To study impacts exerted by exogenous acrolein we examined 156 children in 2014–2016, aged 5–10, attending pre-school facilities and schools, and living in Perm region. As we conducted this research we detected average annual acrolein concentration in atmosphere on the examined territory; this concentration was equal to 0.000024 mg/m3, and it was 1.2 times higher than reference acrolein concentration in the air for chronic inhalation exposure. Average group acrolein concentration in children's blood was 1.2 times authentically higher (р<0.05) than regional background level of acrolein content in blood of children living on conditionally clean (control) territory of Perm region. Average content of malonic dialdehyde in blood plasma and IgG specific to acrolein was 1.2 and 1.4 times authentically higher than physiological standard for these parameters (р<0.05). Average group concentration of delta-aminolevulinic acid in urine was detected at the top limit of physiological standard. Applying odds relation criterion (OR=e a0–a1x ) we obtained authentic models for correlation between acrolein content in blood and G immunoglobulin specific to acrolein, antioxidant activity of blood plasma, crude bilirubin in blood, and delta-aminolevulinic acid in urine (F>3.96, p≤0.05). We used increased content of delta-aminolevulinic acid in urine as a limiting marker for effects occurring at chronic inhalation exposure to acrolein. Basing on the results of the performed examination we recommend concentration equal to 0.10 mgr/dm 3 as a reference level of acrolein content in blood at chronic inhalation exposure.